This review will examine these different aspects of vitamin D metabolism, mechanism of action, and clinical application. Analogs of 1,25(OH) 2D are being developed to target specific diseases with minimal side effects. VDR-regulated transcription is dependent on comodulators, the profile of which is also cell specific. There are thousands of these binding sites regulating hundreds of genes in a cell-specific fashion. 1,25(OH) 2D is the ligand for the vitamin D receptor (VDR), a transcription factor, binding to sites in the DNA called vitamin D response elements (VDREs).

Both 25OHD and 1,25(OH) 2D are catabolized by CYP24A1. CYP2R1 is the most important 25-hydroxylase CYP27B1 is the key 1-hydroxylase.

Vitamin D is metabolized first to 25 hydroxyvitamin D (25OHD), then to the hormonal form 1,25-dihydroxyvitamin D (1,25(OH) 2D). Vitamin D 2 (ergocalciferol) is derived from the plant sterol ergosterol. View the Technical Reports supporting code change.Vitamin D 3 is made in the skin from 7-dehydrocholesterol under the influence of UV light. This section contains reports that are generated to update national and international codes and standards. The research is also used to enhance external standards and codes. Access them free of charge below, at or via our secure client extranet, MyRisk®.įM Global conducts research for use in the data sheets that our engineering field staff use to support our client’s efforts to protect their business. They incorporate nearly 200 years of property loss experience, research and engineering results, as well as input from consensus standards committees, equipment manufacturers and others.įM Global Property Loss Prevention Data Sheets make your business-and the world-more resilient. These exacting standards help you reduce the chance of property loss due to fire, weather conditions, and failure of electrical or mechanical equipment. Look no further than FM Global Property Loss Prevention Data Sheets. To reduce risk at your existing facilities-as well as those under construction-it’s important to have proven engineering guidelines.

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